Vidarabine
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Information for Authority record
Name (Latin)
Vidarabine
Other forms of name
9-b-D-arabinofuranosyladenine
9-beta-arabinofuranosyladenine
9-beta-D-arabinofuranosyladenine
Adenine 9-b-D-arabinofuranoside
Adenine arabinoside
Alpha-ara A (Vidarabine)
Alpha-D-arabinofuranosyladenine
Ara A (Vidarabine)
Ara Ade (Vidarabine)
Arabinofuranosyladenine
Arabinosyladenine
Beta-ara A (Vidarabine)
Vira-A (Vidarabine)
See Also From tracing topical name
Adenosine
Arabinonucleosides
MARC
MARC
Other Identifiers
Library of congress:
sh2017000370
Sources of Information
- Work cat: Chiang, C.-W. Studies on adenine arabinoside-resistant mutants of Toxoplasma gondii, [1998].
- MeSH browser, Feb. 19, 2017(Vidarabine ... An antiviral & antimetabolite. ... A nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the vaccina virus and varicella zoster virus) [UFs] (9-beta-Arabinofuranosyladenine; 9-beta-D-Arabinofuranosyladenine; Adenine arabinoside; Alpha-ara A; Alpha-D-Arabinofuranosyladenine; Ara A; Arabinofuranosyladenine; Arabinosyladenine; Beta-ara A; Vira-A) MeSH tree structures (directly under: Adenosine; also directly under: Arabinonucleosides)
- Dorland's illustrated medical dictionary, 2007(Vidarabine -- a purine analogue that inhibits DNA synthesis; used as a topical antiviral agent in the treatment of herpes simplex keratitis or keratoconjunctivitis and intravenously in the treatment of herpes simplex encephalitis. Called also adenine arabinoside or ara-A)
- Marine drugs, Oct. 11, 2010:p. 2619, doi: 10.3390/md8102619 (Marine sponges are currently one of the richest sources of pharmacologically active compounds found in the marine environment. These bioactive molecules are often secondary metabolites, whose main function is to enable and/or modulate cellular communication and defense. ... The most important antiviral lead of marine origin reported thus far is nucleoside Ara-A (vidarabine) isolated from sponge Tethya crypta. It inhibits viral DNA polymerase and DNA synthesis of herpes, vaccinica and varicella zoster viruses. However due to the discovery of new types of viruses and emergence of drug resistant strains, it is necessary to develop new antiviral lead compounds continuously)
- Biochemical pharmacology, Feb. 15, 2014:p. 543 (Vidarabine is a nucleoside analog that is taken up into host cells and incorporated into the DNA of herpes viruses, thereby leading to inhibition of viral DNA polymerase and DNA chain termination. Via this mechanism, vidarabine, also referred to as adenine 9-b-D-arabinofuranoside or 9-b-D-arabinofuranosyladenine (abbreviated as Ara-A or Ara-Ade), exerts antiviral effects, particularly in herpes virus infections. Vidarabine was the first clinically approved antiviral drug, exhibiting therapeutic effects in local and systemic herpes virus infections. However, due to limitations in clinical efficacy and because of toxicity issues, vidarabine has now been superseded by more effective and safer antiviral agents such as ganciclovir and foscarnet. Currently,the use of vidarabine is restricted to local applications in herpes virus keratitis, with a small therapeutic window)
- Journal of pharmacology and experimental therapeutics, Aug. 2016:p. 244 (Response to letter to the editor on "Does vidarabine mediate cardioprotection via inhibition of AC5?" / Claudio A. Bravo ... . We ... believe that the arguments raised, although partially valid, actually miss the point of our study. We found that vidarabine (AraA) reduced infarct size, even when administered after coronary artery reperfusion, making this drug potentially clinically important, since most drugs must be administered before coronary occlusion in order to be effective)
- Leukemia, Mar. 2000:p. 379 (Fludarabine phosphate (2-F-ara-AMP) is an adenine nucleoside analogue. Unlike adenine arabinoside (ara-A), this drug is water soluble and resistant to deamination by adenosine deaminase)