Signal transducing adaptor proteins
Enlarge text Shrink text-
Topic
|
מספר מערכת
987012575146005171
Information for Authority record
Name (Hebrew)
חלבוני מתאם מתמר אותות
Name (Latin)
Signal transducing adaptor proteins
Other forms of name
Adapter proteins, Signal transducing
Adaptor proteins, Signal transducing
Signal transducing adapter proteins
See Also From tracing topical name
Carrier proteins
MARC
MARC
Other Identifiers
Wikidata:
Q5964993
Library of congress:
sh2018000011
Sources of Information
- Work cat.: Cox, C.L. Dissecting interactions within focal adhesions : studies on vinculin, 2008:abstr. (Vinculin and paxillin are proteins that localise to focal adhesions. ... In this thesis, the molecular nature of the vinculin tail (Vt) and paxillin LD motif interaction has been studied)
- Oncogene, Oct. 2, 2001:p. 6270 (One of the major goals of scientists who study signal transduction is to determine the mechanisms that control cross-talk between signaling cascades and to determine how specificity in signaling is achieved. An emerging class of proteins that are major contributors to these processes are adaptor (or adapter) proteins. Adaptor proteins contain a variety of protein-binding modules that link protein-binding partners together and facilitate the creation of larger signaling complexes. By linking specific proteins together, cellular signals can be propagated that elicit an appropriate response from the cell to the environment. Specificity in signaling would be achieved by the type of protein binding modules encoded by the adaptor protein, the sequence of these domains or motifs that would dictate specificity in binding, as well as the subcellular localization and the proximity of binding partners. Thus, adaptor proteins are positioned to regulate cell signaling in a spatial and temporal fashion)
- Journal of biological chemistry, June 1, 2007:p. 16401 (Adaptor proteins are a unique group of protein-binding partners that are devoid of enzymatic activity but contain at least two modular domains, through which they link signaling components to form macromolecular complexes and propagate cellular signals. Depending on the functional role of the interacting partner and the specific biological event that is triggered by these interactions, adaptor proteins can participate in the regulation of different signaling pathways)
- Mediators of inflammation, 2015:article ID 952536, p. [1] (Signal transducing adaptor proteins are a group of intracellular and transmembrane molecules which are crucial supplementary factors of signaling pathways. They mediate interactions between different molecules and contribute to the formation of signaling complexes. Adaptor proteins lack enzymatic activity and interaction domains enable them to connect with other molecules)
- MeSH browser, Jan. 1, 2018(Adaptor proteins, Signal transducing ... A broad category of carrier proteins that play a role in signal transduction. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymes)
- R&D Systems WWW home page, Jan. 2, 2018:resources/research areas/signal transduction -- adaptor proteins (Adaptor proteins are essential molecules that influence signal transduction pathways, governing cross-talk and specificity. Adaptor proteins contain protein-binding motifs, which facilitate interactions between protein-binding partners and the generation of bigger signaling complexes. Many adaptor proteins are required to link molecules within a signaling cascade to ensure the appropriate signaling response)
1 / 1
File:PDB 1u5e EBI.jpg
Jawahar Swaminathan and MSD staff at the European Bioinformatics Institute, Public domain
Wikipedia description:
Signal transducing adaptor proteins (STAPs) are proteins that are accessory to main proteins in a signal transduction pathway. Adaptor proteins contain a variety of protein-binding modules that link protein-binding partners together and facilitate the creation of larger signaling complexes. These proteins tend to lack any intrinsic enzymatic activity themselves, instead mediating specific protein–protein interactions that drive the formation of protein complexes. Examples of adaptor proteins include MYD88, Grb2 and SHC1.
Read more on Wikipedia >